Title:
【発明の名称】慢性骨髄性白血病の治療剤としての、ソラーレンと結合したメチルりん酸オリゴヌクレオチド
Document Type and Number:
Japanese Patent JPH06500322
Kind Code:
A
Abstract:
Novel reagents which are useful for conjugating a psoralen moiety to an oligomer having at least one non-nucleotide monomeric unit are provided. Also provided are psoralen-conjugated oligomers. Psoralen-conjugated oligomers complementary to the abl gene or bcr/abl of chimeric mRNA are useful in decreasing expression of abl-associated tyrosine kinase and P210 protein.
Inventors:
Buggefi, Morte the M
Reynolds, Mark A.
Arnold, Lyle Jay, Junior
Reynolds, Mark A.
Arnold, Lyle Jay, Junior
Application Number:
JP51415791A
Publication Date:
January 13, 1994
Filing Date:
August 09, 1991
Export Citation:
Assignee:
Jinta Incorporated
International Classes:
A61P35/02; C07D493/04; C07H21/00; C07H21/02; C07K14/47; C07K14/82; A61K48/00; C12N15/09; C12N15/113; C12Q1/68; (IPC1-7): C07H21/02; A61K48/00; C07D493/04; C07H21/00; C12N15/10; C12Q1/68
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)