Title:
【発明の名称】1,2,5,6―テトラヒドロピリジンオキシム誘導体
Document Type and Number:
Japanese Patent JPH06500325
Kind Code:
A
Abstract:
PCT No. PCT/GB91/01456 Sec. 371 Date Feb. 23, 1993 Sec. 102(e) Date Feb. 23, 1993 PCT Filed Aug. 29, 1991 PCT Pub. No. WO92/04323 PCT Pub. Date Mar. 19, 1992.Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 represents a 1,2,5,6-tetrahydropyridin-3-yl group N-substituted by R10 wherein R10 represents hydrogen, C1-2 alkyl, prop-2-enyl, prop-2-ynyl or cyclopropyl, R2 is a group OR4, where R4 is C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, a group OCOR5 where R5 is hydrogen or R4, or a group NHR6, or NR7R8 where R6, R7 and R8 are independently C1-2 alkyl; and R3 is chloro, fluoro, bromo, methoxy, C1-3 alkyl substituted by one, two or three halogen atoms, or R3 is a group (CH2)nR9 where R9 is -CN, -SH or -SCH3 and n is 0 or 1, with the proviso that when n is 0, R9 is not -SH; enhance acetylcholine function via an action at muscarinic receptors within the central nervous system and are therefore of potential use in the treatment and/or prophylaxis of dementia in mammals. (I)
Inventors:
Bromidge, Stephen Mark
Orlek, Barry Sydney
Dove, stephen
Orlek, Barry Sydney
Dove, stephen
Application Number:
JP51439091A
Publication Date:
January 13, 1994
Filing Date:
August 29, 1991
Export Citation:
Assignee:
Beechham Group Public Limited Company
International Classes:
A61K31/445; A61K31/44; A61K31/4406; A61P25/28; C07D211/70; C07D211/78; C07D213/57; (IPC1-7): C07D211/70; A61K31/445
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)