Title:
【発明の名称】上皮細胞成長因子(EGF)との相同性をもつヘパリン結合性マイトジェン
Document Type and Number:
Japanese Patent JPH06502538
Kind Code:
A
Abstract:
PCT No. PCT/US91/07691 Sec. 371 Date Jun. 15, 1993 Sec. 102(e) Date Jun. 15, 1993 PCT Filed Oct. 16, 1991Disclosed are heparin binding mitogens which include an epidermal growth factor-homologous segment (HB-EHM). These factors stimulate proliferation of fibroblast cells, epithelial cells, and smooth muscle cells, but not endothelial cells. Also disclosed are isolated antibodies that recognize, and purified nucleic acids that encode, the above growth factors as well as isolated polypeptides, vectors containing such nucleic acids, and cells harboring such vectors. Growth factors of this invention may be used for accelerating the rate of wound healing, for the in vitro culture of HB-EHM-responsive cells, and for the identification of antagonists to HB-EHM.
Inventors:
Crags Blanc Michael
Abraham Judith A
Higashiyama Shigeki
Besner Gale Yi
Abraham Judith A
Higashiyama Shigeki
Besner Gale Yi
Application Number:
JP50182392A
Publication Date:
March 24, 1994
Filing Date:
October 16, 1991
Export Citation:
Assignee:
The Children's Medical Center Corporation
California Biotechnology Ink
California Biotechnology Ink
International Classes:
A61P43/00; C07K14/475; A61K38/22; C07K16/22; C12N15/09; C12N15/18; C12P21/02; A61K38/00; (IPC1-7): C12N15/18; A61K37/24; C12P21/02
Attorney, Agent or Firm:
Kenji Yoshida (2 outside)