Title:
【発明の名称】増強された安定性及び生物学的活性を有する酸性線維芽細胞成長因子の類似体
Document Type and Number:
Japanese Patent JPH06503962
Kind Code:
A
Abstract:
Novel analogs of aFGF which are provided in accordance with the present invention. These analogs are more stable and exhibit greater biological activity in the absence of heparin than naturally occurring aFGF. Enhanced stability may be achieved by substituting at least one amino acid having a higher loop-forming potential for an amino acid residue having a lower loop-forming potential in the naturally occurring aFGF molecule in the area of amino acids 90 to 97. The novel analogs of the present invention are especially useful in therapeutic applications.
Inventors:
Arakawa, Tutom
Footx, Geary Michael
Footx, Geary Michael
Application Number:
JP50372092A
Publication Date:
May 12, 1994
Filing Date:
December 17, 1991
Export Citation:
Assignee:
Amjien Incorporated
International Classes:
A61P43/00; C07K14/00; C07K14/50; C12N15/09; C12P21/02; A61K38/22; A61K38/00; C12R1/19; (IPC1-7): C12P21/02; A61K37/24; C07K13/00; C12N15/16
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)