Title:
【発明の名称】ウィルス ワクチン
Document Type and Number:
Japanese Patent JPH06504194
Kind Code:
A
Abstract:
A mutant virus for use as a vaccine, wherein the genome of the virus is defective in respect of a gene essential for the production of infectious virus. In one aspect the mutant virus is capable of protecting a susceptible species immunized therewith against infection by the corresponding wild-type virus. In another aspect, the mutant virus acts as a vector for an immunogenic protein derived from a pathogen and which is encoded by foreign DNA incorporated in the mutant virus. The mutant virus can be produced in a recombinant host cell which expresses a gene complementing the defect. The mutant virus is preferably infectious for the host to be protected, but the defective gene allows expression in the infected host of at least some of the viral genes, which can provoke a cell-mediated immune response.
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Inventors:
Inglis, Stephen Charles
Bouaznaire, Michael Edward Griffith
Minson, Anthony Charles
Bouaznaire, Michael Edward Griffith
Minson, Anthony Charles
Application Number:
JP51739991A
Publication Date:
May 19, 1994
Filing Date:
September 23, 1991
Export Citation:
Assignee:
Cantab Pharmaceuticals Research Limited
International Classes:
A61K39/00; A61K39/21; A61K39/245; A61P31/12; A61P31/22; C07K14/155; C12N7/00; C12N7/01; C12N15/09; C12N15/869; (IPC1-7): C12N7/01; A61K39/00; A61K39/21; A61K39/245; C12N15/38
Attorney, Agent or Firm:
Shoichi Ui (3 others)