Title:
【発明の名称】シュウ酸カルシウム結石病の治療用化合物および医薬組成物
Document Type and Number:
Japanese Patent JPH06504290
Kind Code:
A
Abstract:
An extract for the treatment of calcium oxalate kidney stone disease which can be extracted and purified from leaves of the plant Eriobotrya japonica is disclosed. The extract has the following characteristics: inhibits calcium oxalate crystal growth in vitro, inhibits renal calcium oxalate crystal deposition in rats which are fed ethylene glycol, causes rats which are fed ethylene glycol and said extract to excrete less oxalate in their urine as compared to rats which are fed ethylene glycol without said extract, shows little or no loss in activity when exposed to an aqueous solution of pH 1.5 for 14 hours, shows increased activity when exposed to an aqueous solution of pH 12.7 for 15 hours, is polyanionic, is stable when heated in an aqueous solution (at pH of extract) at 98 DEG C. for 3 hours, water-soluble, insoluble in heptane, hexane, chloroform/methanol mix, diethyl ether, and ethanol/aqueous mix, binds to DEAE-A-25 Sephadex at pH 8.6 and is eluted from the DEAE-A-25 Sephadex with 2 M NaCl. The present invention is also directed to a method for the treatment of calcium oxalate stone disease wherein the extract is administered, preferably for a prolonged period of time, to a patient suffering from or prone to calcium oxalate stone disease.
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Inventors:
Costello, Jeramaire
Application Number:
JP50445492A
Publication Date:
May 19, 1994
Filing Date:
January 16, 1992
Export Citation:
Assignee:
Alligeny-Singer Research Institute
International Classes:
A61K36/73; A61K31/191; A61K33/06; A61P13/02; A61P15/00; C07G99/00; (IPC1-7): A61K35/78
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)