Title:
【発明の名称】HIV治療のためのキメラTAR酵素の構築
Document Type and Number:
Japanese Patent JPH06505156
Kind Code:
A
Abstract:
The present invention relates to molecular chimaeras, infective virions, to methods of their construction, to pharmaceutical formulations containing them, to their use in therapy, particularly virus-directed enzyme prodrug therapy particularly in the treatment of HIV, and to the use of agents which can be catalysed by a heterologous enzyme to cytotoxic or cytostatic metabolites, such as purine arabinosides and substituted pyrimidines in virus-directed enzyme prodrug therapy, in a mammalian host (e.g. human).
Inventors:
Hoover, Bryan
Richards, Cynthia Ann
Martin, Jean Lewis
Richards, Cynthia Ann
Martin, Jean Lewis
Application Number:
JP50505592A
Publication Date:
June 16, 1994
Filing Date:
February 26, 1992
Export Citation:
Assignee:
The Welcome Foundation Limited
International Classes:
A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K48/00; A61P31/12; C07H19/09; C07H19/19; C07K14/16; C12N9/12; A61K38/00; (IPC1-7): C12N15/49; A61K31/70; A61K48/00; C07H19/09; C07H19/19; C12N15/52
Attorney, Agent or Firm:
Takehiko Suzue (3 outside)