Title:
【発明の名称】活性因子X111の活性化を阻害するための組成物と方法
Document Type and Number:
Japanese Patent JPH06505496
Kind Code:
A
Abstract:
PCT No. PCT/US92/01926 Sec. 371 Date May 4, 1994 Sec. 102(e) Date May 4, 1994 PCT Filed Mar. 11, 1992 PCT Pub. No. WO92/15609 PCT Pub. Date Sep. 17, 1992Compositions and methods for inhibiting the activation and/or active state of a precursor protein are provided. Compositions provided can bind to a cleavage site of a precursor protein. Also provided are compounds useful for generating inhibitor compositions. Application of the invention to the treatment of myocardial infarction and other thrombotic conditions is specifically provided. Further provided are antibodies specific for active Factor XIII.
Inventors:
Guy Elle, Reed
Matsueda, Garry Earl
Harbor, edgar
Matsueda, Garry Earl
Harbor, edgar
Application Number:
JP50831892A
Publication Date:
June 23, 1994
Filing Date:
March 11, 1992
Export Citation:
Assignee:
The General Hospital Corporation
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
International Classes:
A61K38/55; A61P7/02; C07K7/06; C07K14/745; C07K14/755; C07K16/00; C07K16/40; C12N9/10; A61K38/00; A61K39/00; (IPC1-7): C07K7/06; A61K37/64; C07K15/06
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)