Title:
【発明の名称】レチノイド様生物学的活性を有する7位にヘテロアリールエチニル置換基を有するクロマンおよびチオクロマン
Document Type and Number:
Japanese Patent JPH06506935
Kind Code:
A
Abstract:
Novel compounds of the formula where X is S, O; R1-R5 are hydrogen or lower alkyl; R6 is lower alkyl, lower alkenyl, lower cycloalkyl having 1 to 6 carbons, or halogen; A is lower branched chain alkyl having 2 to 6 carbons, cycloalkyl having 3 to 6 carbons, alkenyl having 2 to 6 carbons and 1 or 2 double bonds, alkynyl having 2 to 6 carbons and 1 or 2 triple bonds, (CH2)n where n is 0-5; and B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR8, COONR9R10, -CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12)2, CHOR13O, -COR'', CR''(OR12)2, or CR''OR13O, where R'' is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R8 is an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R8 is phenyl or lower alkylphenyl, R9 and R10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or phenyl or lower alkylphenyl, R11 is lower alkyl, phenyl or lower alkylphenyl, R12 is lower alkyl, and R13 is a divalent alkyl radical of 2-5 carbons, have retinoic acid like activity.
Inventors:
Chandra Ratna, Roshansa A.S.
Application Number:
JP50958892A
Publication Date:
August 04, 1994
Filing Date:
March 25, 1992
Export Citation:
Assignee:
ALLERGAN,INCORPORATED
International Classes:
A61K8/49; A61K8/00; A61K31/38; A61K31/42; A61K31/425; A61K31/443; A61K31/4433; A61K31/4436; A61K31/50; A61K31/505; A61P17/00; A61Q19/00; C07D405/06; C07D409/06; C07D413/06; C07D417/06; (IPC1-7): C07D409/06; A61K7/00; A61K7/48; A61K31/38; A61K31/42; A61K31/425; A61K31/50; A61K31/505; C07D405/06; C07D409/06; C07D413/06; C07D417/06
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)