Title:
【発明の名称】5-HT↓1↓a拮抗物質及び5-HT↓2 拮抗物質としてのベンゾイミダゾロン誘導体
Document Type and Number:
Japanese Patent JPH06509575
Kind Code:
A
Abstract:
Pharmacologically active benzimidazolone derivatives as 5-HT1A and 5-HT2 receptors, useful in the treatment of CNS disorders of formula: wherein R1 and R2 may be at the same time or not a hydrogen atom, halogen, trifluoromethyl, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 acyl, carboxyl, C1-6 alkoxy- carbonyl, hydroxy, nitro, amino optionally C1-4 alkyl N-mono or di-substituted, C1-6 acylamino, C1-6 alkoxycarbonylamino, carbamoyl optionally C1-4 alkyl N-mono or di-substituted, cyano, C1-6 alkylsulphinyl, C1-6 alkylsulphonyl, amino sulphonyl optionally C1-4 alkyl N-mono or di-substituted, C1-4 alkyl N-mono or di-substituted aminosulphonylamino, aminosulphonylamino; R3 is hydrogen, C1-6 alkyl, C2-6 alkenyl or C2-C6 alkynyl; A is -CO- or -CONH- or it is absent; B is a straight or branched, saturated or unsaturated C2-6 alkyl; m and n are both independently an integer from 1 to 3; R4 is an aryl, aralkyl, a heteroaryl or heteroaralkyl group, each group being optionally substituted by one or more substituents selected from halogen, trifluoromethyl, cyano, C1-3 alkoxy, C1-4 alkyland acid addition salts thereof. The process for the preparation of the compounds of formula I as well as pharmaceutical compositions containing them are also described.
Inventors:
Bietti Giuseppe
Borsini franco
Turconi Marco
Girard Ettore
Bignotti Maura
Borsini franco
Turconi Marco
Girard Ettore
Bignotti Maura
Application Number:
JP50345393A
Publication Date:
October 27, 1994
Filing Date:
July 30, 1992
Export Citation:
Assignee:
Boehringer Ingelheim Italy Societa Peratini
International Classes:
A61K31/00; A61K31/397; A61K31/41; A61K31/495; A61K31/4184; A61K31/496; A61K31/505; A61K31/506; A61K31/55; A61P9/00; A61P25/00; A61P25/04; A61P43/00; C07D235/26; C07D403/06; C07D403/12; C07D405/12; (IPC1-7): C07D403/12; A61K31/495; C07D403/06
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)