Title:
【発明の名称】サプレッサーおよび前駆細胞
Document Type and Number:
Japanese Patent JPH06510672
Kind Code:
A
Abstract:
Natural suppressor (NS) cells secrete a soluble protein suppressor factor (SF) which suppresses the mixed lymphocyte response. NS cells as described herein are null, i.e., have the phenotype IL-2R<+>, CD3<->, CD4<->, CD8<->, TCR alpha beta <->, Ig<->, MAC-1<->, or are double negative suppressors (DNS); i.e., have the phenotype IL-2R<+>, CD3<+>, CD4<->, CD8<->, TCR alpha beta <+>. Both NS and SF are useful in vivo to confer immunotolerance with respect to allogeneic transplants, and to effect immunosuppresion. They also enhance engraftment of transplanted cells. A population of cells can be provided using density gradient separation techniques which is enriched in progenitor cells as identified by the presence of CD34 surface markers.
Inventors:
Strober, Samuel S.
Application Number:
JP50876892A
Publication Date:
December 01, 1994
Filing Date:
November 05, 1992
Export Citation:
Assignee:
INTERNATIONAL BUSINESS MACHINES CORPORATION
International Classes:
A61K35/14; A61K38/00; A61P7/06; A61P37/06; C07K1/16; C07K1/22; C07K14/435; C07K14/52; C07K14/54; C07K14/55; C07K16/00; C07K16/24; C12N5/0783; C12N5/0789; C12N5/10; C12N15/09; C12N15/19; C12P21/02; A61K35/12; C12R1/91; (IPC1-7): C12N5/10; A61K35/14; A61K37/02; C07K3/20; C07K15/06; C12N15/12; C12P21/02
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)