Title:
【発明の名称】5-オキソプロスタグランジンE▲下1▼類及びその製法
Document Type and Number:
Japanese Patent JPH07116134
Kind Code:
B2
Abstract:
NEW MATERIAL:The compound of formula I [the double line is cis or trans double bond; G<1> is -CO2R<5> (R<5> are H, 1-10C alkyl, etc.), etc.; R<1> is H, methyl, etc.; R<2> is unsubstituted 5-8C alkyl, (substituted) alicyclic group, etc.; R<3> and R<4> are H, 2-7C acyl, etc.; n is 0 or 1], its enantiomer or their mixture at arbitrary ratio. EXAMPLE:5-Oxoprostaglandin E1 methyl ester. USE:The compound is expected to be useful as an anticoagulant, antiulcer agent, cell protection agent for liver and kidney, etc. PREPARATION:The compound of formula I can be produced by reacting 5,6- dehydroprostaglandin E2s of formula II (R<31> and R<41> are same as R<3> and R<4> or H; G is same as G<1>) with a palladium (II) compound in an inert medium and optionally subjecting the reaction product to deprotection or hydrolysis.
More Like This:
Inventors:
Kiichiro Uchimoto
Seiji Kurosumi
Seiji Kurosumi
Application Number:
JP99287A
Publication Date:
December 13, 1995
Filing Date:
January 08, 1987
Export Citation:
Assignee:
Teijin Limited
International Classes:
A61K31/557; A61K31/5575; A61P1/04; C07F7/18; A61P1/16; A61P7/02; A61P13/02; A61P15/00; A61P43/00; C07C67/00; C07C401/00; C07C405/00; (IPC1-7): C07C405/00; C07F7/18
Attorney, Agent or Firm:
Maeda Junhiro