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Title:
【発明の名称】3′-末端封鎖されたオリゴヌクレオチド
Document Type and Number:
Japanese Patent JPH07501314
Kind Code:
A
Abstract:
The invention provides oligonucleotides having 3'-ends blocked by cap structures and having one or more artificial internucleoside linkage. Such oligonucleotides are resistant to in vivo degradation and extension, and thus have superior half-life in vivo.

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Inventors:
Agrawal, Sudir
Tensamani, Jamal
Tan, Jin-Yang
Application Number:
JP50010993A
Publication Date:
February 09, 1995
Filing Date:
May 08, 1992
Export Citation:
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Assignee:
High Brydon Inc.
International Classes:
A61K31/70; A61K31/7088; A61K48/00; A61P31/12; C07H21/00; (IPC1-7): C07H21/00; A61K31/70; A61K48/00; C12N15/11
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)



 
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