Title:
【発明の名称】治療ペプチドの脂質共役体およびプロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JPH07501316
Kind Code:
A
Abstract:
Compounds wherein therapeutic peptides, including HIV protease inhibitors, are covalently linked to phospholipids, glycerides or other membrane-targeting and membrane-anchoring species, and their pharmaceutically acceptable salts, together with processes for their preparation. The invention also provides novel HIV protease inhibitors. The compounds of the present invention possess useful pharmacological properties such as antiviral activity towards viral infection and inhibitory activity towards viral proteases. Therefore, these compounds can be used in the prophylaxis or treatment of viral infections, in particular infections caused by HIV and other retroviruses. The targeting technology as described for the protease inhibitors is also applicable to a variety of inhibitors of other enzymes.
Inventors:
Bhasaba, Chana
Karst Wye
Karst Wye
Application Number:
JP50306493A
Publication Date:
February 09, 1995
Filing Date:
July 22, 1992
Export Citation:
Assignee:
NEXT STAR PHARMACEUTICALS INC.
International Classes:
A61K38/00; A61K38/55; A61P31/12; C07C69/96; C07F9/10; C07K1/00; C07K1/107; C07K1/113; C07K5/02; C07K5/06; C07K5/072; C07K5/08; C07K5/083; C07K5/097; C07K5/10; C07K5/103; C07K5/107; C07K7/02; C07K7/06; C07K7/08; C07K11/00; C07K14/155; C07K14/16; C07K14/81; (IPC1-7): C07K7/06; A61K38/00; A61K38/55; C07K5/02; C07K5/06; C07K5/08; C07K5/10; C07K7/02; C07K7/08; C07K14/155
Attorney, Agent or Firm:
Fukami Hisaro (3 outside)