Title:
【発明の名称】複数のCTP付加を有するホルモンアナログ
Document Type and Number:
Japanese Patent JPH07502166
Kind Code:
A
Abstract:
"Partial" and "complete" CTP units are used to modify biologically active proteins and peptides at the aminoterminus to alter their clearance patterns. "Complete" CTP units have the amino acid sequence found at positions 112-118 to position 145 of the beta -subunit of human chorionic gonadotropin; "partial" CTP units are missing at least one amino acid in the region of position 118-145 inclusive. Variants of these CTP units contain 1-5 conservative amino acid substitutions which do not destroy activity. Suitable peptides or proteins which may be modified in this manner include various hormones and cytokines.
Inventors:
Boim, Irving
Application Number:
JP50709393A
Publication Date:
March 09, 1995
Filing Date:
October 02, 1992
Export Citation:
Assignee:
Washington University
International Classes:
A61K38/24; A61K39/395; C07K14/575; C07K14/59; C07K16/00; C07K16/26; C07K19/00; C12N1/19; C12N1/21; C12N15/09; C12N5/10; C12N15/00; C12N15/16; C12P21/00; A61K38/00; C12R1/91; (IPC1-7): C12P21/00; C07K14/59; C12N1/19; C12N1/21; C12N5/10; C12N15/09
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)