Title:
【発明の名称】嚢胞性繊維症膜貫通型コンダクタンス調節活性(CFTR)のための遺伝子治療
Document Type and Number:
Japanese Patent JPH07502510
Kind Code:
A
Abstract:
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Lipid carrier-nucleic acid complexes or nucleic acid abre are prepared then delivered via aerosol or systemically to the lung abre or lung plus extrapulmonary tissues. The invention provides a direct method for transforming pulmonary cells as a means for treating the manifestations of CF in the lung and involved extrapulmonary tissues.
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Inventors:
Debs, Robert Jay.
Two, Nin
Two, Nin
Application Number:
JP51119593A
Publication Date:
March 16, 1995
Filing Date:
December 17, 1992
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
C12N15/09; A61K9/00; A61K9/127; A61K31/70; A61K47/48; A61K48/00; C07K14/00; C07K14/47; C07K14/55; C12N15/88; A61K39/00; (IPC1-7): A61K31/70; A61K48/00; C12N15/09
Attorney, Agent or Firm:
Atsushi Nakajima (2 outside)