Title:
【発明の名称】IFN受容体認識因子,そのタンパク質配列および使用方法
Document Type and Number:
Japanese Patent JPH07505524
Kind Code:
A
Abstract:
Receptor recognition factors exist that recognize the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN alpha and IFN gamma . Specific DNA sequences have been prepared that correspond to polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
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Inventors:
Schindler Christian W
Houghton, Michael A.
Shoe eye
Applied Biosystems, Inc.
Houghton, Michael A.
Shoe eye
Applied Biosystems, Inc.
Application Number:
JP51676193A
Publication Date:
June 22, 1995
Filing Date:
March 19, 1993
Export Citation:
Assignee:
The Rockefeller University
International Classes:
G01N33/53; A61K38/00; A61K38/21; A61K39/395; A61K49/00; A61P1/16; A61P31/12; A61P35/00; A61P35/02; A61P43/00; C07K14/47; C07K14/52; C07K14/555; C07K14/56; C07K14/57; C07K16/00; C07K19/00; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12P21/08; (IPC1-7): C12P21/02; A61K38/00; A61K38/21; A61K39/395; A61K49/00; C07K14/52; C12N1/21; C12N5/10; C12N15/09; C12P21/08; G01N33/53
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)