Title:
【発明の名称】胃酸分泌阻害作用を有する物質と酸分解性抗生物質の相乗作用配合物
Document Type and Number:
Japanese Patent JPH07505901
Kind Code:
A
Abstract:
The invention consists of a combination of a substance that increases the intragastric pH and an acid degradable antibacterial compound. By this combined product regimen it will be possible to obtain maximal local antibacterial effect of acid degradable antibiotics as well as enhanced bioavailability of the active antibiotic, thus resulting in higher amounts of the active compound in the gastric mucosa due to secretion of weak bases. Both pharmacological effects contribute to drastically increased antimicrobial capacity of acid degradable antibiotics to be used against local infections in the gastrointestinal tract causing gastritis and/or peptic ulcer. The invention also selects to the use of said combination and a process for the preparation thereof.
Inventors:
Arne Torsten, Ek
Sie Strand, Sven Erik
Sie Strand, Sven Erik
Application Number:
JP51916493A
Publication Date:
June 29, 1995
Filing Date:
April 20, 1993
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
A61B17/04; A61B17/06; A61K31/00; A61K45/06; A61K31/335; A61K31/43; A61K31/44; A61K31/70; A61P1/00; A61P1/04; A61B17/34; A61F2/00; C07D401/00; C07D403/00; (IPC1-7): A61K45/06; A61K31/335; A61K31/43; A61K31/44; A61K31/71
Attorney, Agent or Firm:
Chika Takagi (2 outside)