Document Type and Number:
Japanese Patent JPH07506829
Kind Code:
A
Abstract:
A compound of structural Formula I: +TRthereof wherein: each n is independently 1 to 3; Y is chosen from a-n as defined herein; wherein each occurrence of said C1-6 alkyl may be substituted with one or more F, Cl, Br, I, OR1, CO2R1, CN, SR1, or R1 (where R1 is a hydrogen or C1-4 alkyl); X and Z are independently C1-6 alkyl, C3-12 cycloalkyl or hydrogen, or X and Z form a C0-3 bridging group, preferably X and Z are hydrogen; U, V and W are independently C1-6 alkyl, F, Cl, Br, hydrogen or a C1-6 alkyl substituted with one or more of F, Cl, Br or I, preferably U and V are F and W is hydrogen; R is hydrogen, C1-12 alkyl, C3-12 cycloalkyl, C1-6 alkoxy, C1-6 alkyl substituted with one or more F, Cl, Br, I or OH; and q is 0 to 4 inclusive. Oxazolidinone derivatives possessing a substituted diazine moiety bonded to the N-aryl ring are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including multiply-resistant staphylococci and streptococci, as well as anaerobic organisms such as bacteroides and clostridia species, and acid-fast organisms such as Mycobacterium tuberculosis and Mycobacterium avium.
More Like This:
Application Number:
JP52022693A
Publication Date:
July 27, 1995
Filing Date:
April 21, 1993
Export Citation:
International Classes:
A61K31/395; A61K31/42; A61K31/421; A61K31/422; A61K31/495; A61K31/496; A61K31/551; A61P31/00; A61P31/04; C07D263/20; C07D263/24; C07D413/10; C07D413/12; C07D413/14; (IPC1-7): C07D263/20; A61K31/42; A61K31/495; C07D263/24; C07D413/12