Document Type and Number:
Japanese Patent JPH07508705
Kind Code:
A
Abstract:
An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R1 where a substantially geometrically pure first precursor having the structure (* CHEMICAL STRUCTURE *) and a second precursor are provided, the second precursor being a 1,7 enyne. These precursors are reacted in the presence of a palladium catalyst to form compounds having the structure (* CHEMICAL STRUCTURE *) where R2 hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group, and R3 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group.
Application Number:
JP51420193A
Publication Date:
September 28, 1995
Filing Date:
February 05, 1993
Export Citation:
International Classes:
B01J31/18; B01J31/24; C07B37/04; C07B37/10; C07B61/00; C07C2/86; C07C13/465; C07C17/26; C07C17/272; C07C22/00; C07C23/18; C07C29/44; C07C33/44; C07C35/21; C07C41/30; C07C43/178; C07C401/00; C07F7/18; (IPC1-7): C07C2/86; C07B37/04; C07C13/465; C07C17/272; C07C22/00; C07C23/18; C07C29/44; C07C33/44; C07C35/21; C07C41/30; C07C43/178; C07C401/00; C07F7/18