Title:
【発明の名称】タキソール、関連タキサン及び他の新規な抗癌/抗ウイルス性化合物原料としてのイチイ培養組織
Document Type and Number:
Japanese Patent JPH08500973
Kind Code:
A
Abstract:
Successful culture methods have been developed which result in stable, long-term tissue cultures derived from Taxus explants and hydroponically grown roots. These cultures offer a rapidly reproducible, continuously-available source for the production of purified taxol and taxol-related compounds. Culture methods include in vitro tissue culture and hydroponics. Cultures are initiated with stem or root tissues of Taxus or from roots grown hydroponically. Taxol production may be scaled to commercial levels by use of bioreactors. Screening assays are provided for species and cultures of Taxus that are sources of taxol and taxol-related compounds. In addition to obtaining the same compositions as presently directly extracted from yew trees, new compositions exhibiting taxol-like activity, have been purified from the novel Taxus sources, offering new horizons for chemotherapeutic agent development.
Inventors:
Artica richard n
Wick Reme Shinhe Enakusha
Wick Reme Shinhe Enakusha
Application Number:
JP50369094A
Publication Date:
February 06, 1996
Filing Date:
May 11, 1993
Export Citation:
Assignee:
The Penn State Research Foundation
International Classes:
A01H4/00; A61K31/335; A61K31/337; A61K36/18; A61P35/00; C07D305/14; C12N5/04; C12P17/02; (IPC1-7): C12N5/04; A01H4/00; A61K31/335; A61K35/78; C07D305/14; C12P17/02
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)