Title:
【発明の名称】抗生物クリプトジンペプチド及びその使用方法
Document Type and Number:
Japanese Patent JPH08501070
Kind Code:
A
Abstract:
The present invention provides substantially purified cryptdin peptides characterized as being cationic and between 30 and 40 amino acids in length, being found naturally in the epithelial cells of the small intestine, exhibiting specific antimicrobial activity against intestinal pathogens, and having a consensus amino acid sequence as follows: X1-C-X2-C-R-X3-C-X4-E-X5-G-X6-C-X7-C-C-X8, wherein X1 is 3-6 amino acids; X2 is one amino acid; X3 is 2 or 3 amino acids; X4 is three amino acids; X5 is three amino acids; X6 is one amino acid; X7 is 6 to 10 amino acids; and X8 is 0 to 7 amino acids. The preferred embodiments are illustrated as mouse cryptdin-1 (SEQ ID NO:9), mouse cryptdin-2 (SEQ ID NO:10), mouse cryptdin-3 (SEQ ID NO:11), mouse cryptdin-4 (SEQ ID NO:12), mouse cryptdin-5 (SEQ ID NO:13), and rat cryptdin-1 (SEQ ID NO:14). The present invention provides a method for detecting inflammatory pathologies in a subject and, further, provides a method for treating an infectious process by the administration of the cryptdin peptides in a physiologically acceptable medium.
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Inventors:
Celested, Michael E.
Ulette, Andre Jay.
Mirror, Samuel Eye.
Ulette, Andre Jay.
Mirror, Samuel Eye.
Application Number:
JP50085294A
Publication Date:
February 06, 1996
Filing Date:
May 26, 1993
Export Citation:
Assignee:
The Regents of the University of California
Shriners Hospital Four Cripple Children
The General Hospital Corporation
Shriners Hospital Four Cripple Children
The General Hospital Corporation
International Classes:
A61K9/22; A61K38/00; A61K39/395; A61P1/00; A61P29/00; C07K14/46; C12P21/08; C07K14/47; C07K16/18; G01N33/564; G01N33/569; G01N33/68; (IPC1-7): C07K14/46; A61K9/22; A61K38/00; A61K39/395; C07K16/18; C12P21/08
Attorney, Agent or Firm:
Atsushi Nakajima (5 people outside)