Title:
【発明の名称】リンパの搬送組成物
Document Type and Number:
Japanese Patent JPH08501534
Kind Code:
A
Abstract:
A composition for delivering an active agent to the lymphatic system comprises a plurality of colloidal particles and an active agent associated with each particle, wherein the surface of each particle has a hudrophobicity ratio as defined of less than 10, or wherein a modifying agent is adsorbed onto the surface of each particle such that the modifying agent gives an advancing contact angle as defined of less than 60 DEG or wherein the adsorbed layer thickness as defined is less than 10 nm or the albumin uptake ratio is between 0.2 and 0.5. The composition may satisfy one or more of these requirements. Preferred modifying agents are non-ionic surfactants, in particular block copolymers containing polyethyleneglycol.
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Inventors:
Davis, Stanley S
Ilam, Lisbeth
Christie, Nikola
Mogimi, Moaine
Ilam, Lisbeth
Christie, Nikola
Mogimi, Moaine
Application Number:
JP50432993A
Publication Date:
February 20, 1996
Filing Date:
July 28, 1993
Export Citation:
Assignee:
Dan Biocyst Uk Limited
International Classes:
A61K9/14; A61K9/51; A61K47/48; A61K49/00; (IPC1-7): A61K9/51; A61K47/48; A61K49/00
Attorney, Agent or Firm:
Masatake Shiga (2 outside)