Title:
【発明の名称】酵素的に制御された薬剤放出のための架橋されたポリヒドロキシ材料
Document Type and Number:
Japanese Patent JPH08502036
Kind Code:
A
Abstract:
The present application is concerned with a solid slow release pharmaceutical dosage unit. More specifically, the invention is directed to a tablet form prepared by direct compression of cross-linked amylose (CLA) having a definite cross-linking degree, (alpha)-amylase and a pharmaceutical agent. The presence of the cross-linked amylose allows a sustained release of the drug, while the (alpha)-amylase permits the modulation of the release time. In other words, the release time of the drug is function of the amount of (alpha)-amylase in the tablet. The amount of (alpha)-amylase is defined in terms of Enzyme Units.
Inventors:
Mattisk, Myrcia A
Damolin, Eve
Cartier, Louis
Rena Erz, Vincent
Damolin, Eve
Cartier, Louis
Rena Erz, Vincent
Application Number:
JP50404894A
Publication Date:
March 05, 1996
Filing Date:
July 22, 1993
Export Citation:
Assignee:
Rabo Farm Incorporated
International Classes:
A61K9/20; A61K9/22; A61K47/36; A61K47/42; (IPC1-7): A61K47/36; A61K9/22; A61K47/42
Attorney, Agent or Firm:
Takehiko Suzue (3 outside)