Title:
【発明の名称】イノシトール1,4,5‐トリスホスフェートを拮抗する方法
Document Type and Number:
Japanese Patent JPH08502068
Kind Code:
A
Abstract:
Oligomers of formula (I) have been demonstrated to be effective antagonists of inositol 1,4,5-triphosphate (IP3) by competitively vying with IP3 for binding sites. By competitively inhibiting the activity of IP3, the oligomers of this invention can modulate the release of intracellular calcium and elicit the resultant physiological effects.
Inventors:
Storderman, Kenneth A.
Application Number:
JP50905494A
Publication Date:
March 05, 1996
Filing Date:
August 30, 1993
Export Citation:
Assignee:
Merrell Dow Pharmaceuticals Inc.
International Classes:
A61K31/17; A61K31/795; A61P43/00; C07C309/51; A61K31/785; C08G71/02; (IPC1-7): A61K31/785; C07C309/51; A61K31/17
Attorney, Agent or Firm:
Katsuro Sasai