Title:
【発明の名称】1,3-オキサゾリジン-5-カルボン酸の製造方法
Document Type and Number:
Japanese Patent JPH08503485
Kind Code:
A
Abstract:
PCT No. PCT/FR93/01133 Sec. 371 Date May 19, 1995 Sec. 102(e) Date May 19, 1995 PCT Filed Nov. 18, 1993 PCT Pub. No. WO94/12482 PCT Pub. Date Jun. 9, 1994Method for the preparation of 1,3-oxazolidin 5-carboxylic acid having the general formula (I) ormula (II) (II) In the general formulas (I) and (II), Ar is an aryl radical, R1 is a benzoyl radical or a radical R2-O-CO- wherein R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical, Ph is an optionally substituted phenyl radical, X is the residue of an optically active organic base or an alkoxy radical optionally substituted by a phenyl radical. The acids of formulas (I) and (II) are particularly useful in preparing taxol, Taxotere or analogs thereof which have remarkable antitumor and antileukemia properties.
Inventors:
Deni, Jean-Noel
Green,andreux
Kanazawa, Alice
Green,andreux
Kanazawa, Alice
Application Number:
JP51283694A
Publication Date:
April 16, 1996
Filing Date:
November 18, 1993
Export Citation:
Assignee:
Loan-Poulin L'Oré Societe Anonym
International Classes:
C07D263/04; C07D263/06; (IPC1-7): C07D263/06
Attorney, Agent or Firm:
Heiyoshi Odashima