Title:
【発明の名称】ヒト癌腫抗原(HCA)、HCA抗体、HCA免疫アッセイ法、画像化の方法及び治療
Document Type and Number:
Japanese Patent JPH08506815
Kind Code:
A
Abstract:
A glycoprotein antigen which is generally characteristic of human carcinomas, regardless of the tissue associated with the carcinoma-human carcinoma antigen (HCA)-and which is generally not present on normal human cells. Immunodeterminant-containing fragments of HCA substantially separated from elements of HCA's naturally occurring environment are also disclosed. HCA is generally characterized by: a) a molecular weight in excess of 750,000; b) carbohydrate moieties characteristic of mucin-type glycoproteins and comprising a relatively high proportion of sialic acid, galactose, and N-acetylgalactosamine residues (e.g., at least 50% of the carbohydrate residues are sialic acid, galactose, or N-acetylgalactosamine residues); c) an isoelectric point below pH 3.0; d) presence generally on human carcinoma cells; e) absence generally from non-transformed human cells; f) at least one immunodeterminant that specifically reacts with anti-murine epiglycanin antibody AE3; and g) general insolubility in aqueous fluids (e.g., a phosphoric acid or an HCl solution) below pH 2.0. Also disclosed are antibodies to HCA, immunoassays for HCA and in vivo imaging using HCA-binding antibodies.
Inventors:
Coddington John F.
Harvic svain
Harvic svain
Application Number:
JP51829994A
Publication Date:
July 23, 1996
Filing Date:
February 07, 1994
Export Citation:
Assignee:
Epigen, Ink.
International Classes:
A61K39/00; A61K39/395; A61K49/00; A61K51/00; A61K51/10; A61P35/00; C07K14/47; C07K14/705; C07K16/30; C07K16/42; C12P21/08; G01N33/574; G01N33/577; G01N33/68; A61K38/00; A61K48/00; (IPC1-7): C07K14/705; A61K39/00; A61K39/395; A61K49/00; A61K51/00; C07K16/30; C07K16/42; C12P21/08; G01N33/574; G01N33/577
Attorney, Agent or Firm:
Shimizu Hatsushi