Title:
【発明の名称】2-ベンジル-多環式グアニン誘導体およびそれらの製造方法
Document Type and Number:
Japanese Patent JPH08507068
Kind Code:
A
Abstract:
PCT No. PCT/US94/01728 Sec. 371 Date Nov. 26, 1996 Sec. 102(e) Date Nov. 26, 1996 PCT Filed Feb. 24, 1994 PCT Pub. No. WO94/19351 PCT Pub. Date Sep. 1, 1994Antihypertensive and bronchodilating compounds of the formula or a pharmaceutically acceptable salt thereof, and a process for preparing them are disclosed, wherein: R1, R2, R3, Ra, Rb and Rc as defined in the disclosure; pharmaceutical compositions containing said compounds; methods of treatment using said compounds; and a process for preparing polycyclic guanines comprising a) reducing a nitrosopyrimidine, and treating the reduced nitrosopyrimidine with an acylating reagent to give the amidopyrimidine; b) reacting the amidopyrimidine with a halogenating/cyclizing reagent to give a halopurine; c) reacting, in the presence of a base, the halopurine with an amine to give the substituted aminopurine; and d) closing the ring of the substituted aminopurine with a suitable dehydrating agent.
Inventors:
Dean, Tarsian
McKitrick, Brian A.
Shah, Yang
Chakkala Manil, Samuel
Gala, Dinesh
Di Benedetto, Donald Jay
Kugerman, Max
McKitrick, Brian A.
Shah, Yang
Chakkala Manil, Samuel
Gala, Dinesh
Di Benedetto, Donald Jay
Kugerman, Max
Application Number:
JP51913994A
Publication Date:
July 30, 1996
Filing Date:
February 24, 1994
Export Citation:
Assignee:
SCHERING CORPORATION
International Classes:
C07D239/54; C07D473/40; C07D487/14; C07D487/20; (IPC1-7): C07D487/14
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)