Title:
【発明の名称】平滑筋細胞増殖の阻害についてのカルバゾリル-▲(4)▼-オキシプロパノールアミン化合物の使用および該化合物を用いる治療法
Document Type and Number:
Japanese Patent JPH08508013
Kind Code:
A
Abstract:
A new use of, and method of treatment using, a compound selected from the group consisting essentially of compounds of formula (I) wherein: R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl; R3 is hydrogen or lower alkyl of up to 6 carbon atoms; R4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R4 together with R5 can represent -CH2-O-; X is a valency bond, -CH2, oxygen or sulfur; Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl; R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a -CONH2- group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkysulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms; or R5 and R6 together represent methylenedioxy; or a pharmaceutically acceptable salt thereof, for inhibition of proliferation of smooth muscle cells. The new use of, and method of treatment using, the present antiproliferative compounds prevent restenosis following percutaneous transluminal coronary angioplasty (PTCA) and prevent development of atherosclerosis.
Inventors:
Allstein, Elliott H.
Application Number:
JP51993794A
Publication Date:
August 27, 1996
Filing Date:
August 27, 1993
Export Citation:
Assignee:
Boehringer Mannheim Pharmaceuticals Corporation-SmithKline Beecham Corporation Limited Partnership Number 1
International Classes:
A61K31/40; A61K31/403; A61P9/00; A61P9/10; A61P9/12; C07D209/88; (IPC1-7): A61K31/40; A61K31/40
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)