Title:
【発明の名称】ヒトカルシウムセンサー
Document Type and Number:
Japanese Patent JPH08510135
Kind Code:
A
Abstract:
The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is propsed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.
Inventors:
Akerstrom, Golan
Clare Cog, Lars
Julin, Claes
Rusk, Lars
Clare Cog, Lars
Julin, Claes
Rusk, Lars
Application Number:
JP52585794A
Publication Date:
October 29, 1996
Filing Date:
May 24, 1994
Export Citation:
Assignee:
Akerstrom, Golan
Clare Cog, Lars
Julin, Claes
Rusk, Lars
Clare Cog, Lars
Julin, Claes
Rusk, Lars
International Classes:
C12N15/09; A61K38/00; A61P3/02; A61P3/14; C07H21/04; C07K14/47; C07K14/705; C12N5/10; C12P21/02; (IPC1-7): C12N15/09; A61K38/00; C07H21/04; C07K14/47; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Akira Asamura (3 outside)