Title:
【発明の名称】プロリルエンドペプチダ-ゼ阻害作用を有する新規ピロリジンアミド誘導体
Document Type and Number:
Japanese Patent JPH08806
Kind Code:
B2
Abstract:
A novel pyrrolidineamide derivative that exhibits inhibitory activity toward prolyl endopeptidase and its use as an inhibitor against said enzyme are provided. The pyrrolidineamide of the invention has the following general formula: wherein R<1> is benzyloxycarbonyl or a group of the formula: (wherein m is an integer of from 1 to 5) and R<2> is hydroxy, acyloxy or a group of the formula: (wherein R<3> and R<4> independently are a hydrogen atom, a halogen atom, a lower alkyl or a lower alkoxy). Pharmaceutical compositions comprising such derivatives are also provided together with processes for the production of the derivatives. The use of the derivatives for the manufacture of medicaments of therapeutic value is also provided.
Inventors:
Masayuki Saito
Ryuji Tanaka
Naoki Higuchi
Hashimoto Masaki
Shinichi Fukami
Ryuji Tanaka
Naoki Higuchi
Hashimoto Masaki
Shinichi Fukami
Application Number:
JP27435586A
Publication Date:
January 10, 1996
Filing Date:
November 18, 1986
Export Citation:
Assignee:
Suntory Limited
International Classes:
A61K31/401; A61P25/28; A61P43/00; A61K31/40; C07D207/16; C12N9/99; (IPC1-7): C07D207/16; A61K31/40; C12N9/99
Domestic Patent References:
| JP1104076A |
Attorney, Agent or Firm:
Kyozo Yuasa (4 outside)
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