Title:
【発明の名称】ピリダジノキノリン化合物
Document Type and Number:
Japanese Patent JPH09504519
Kind Code:
A
Abstract:
(4,5-b)quinoline-1,10-dione derivs. and tricyclic hetero-fused pyridazino-pyridine analogues of formula (I) and their salts and tautomers are new, including B-ring tautomers or reduced derivs. of formula (I'):Z = O, S or NH; Z1 = H, OH, SH or NH2; ring A = ortho-fused phenyl, pyridyl, furyl,etc.; R4 = halo, Q, NO2, CN, 1-3C perfluoroalkyl, OH,etc.;R1 = H or -(CH2)nL; L = M or W; M = e.g. (i) phenyl (or benzo deriv.), opt. substd. by 1-4 of OQ, 2-4C alkenyloxy, 2-4C alkynyloxy,-OCOQ'-phenyl,etc.;(ii) 5-7 membered heterocyclyl contg. 1-3 of O, N and S as heteroatoms,etc.;or (iii) heteroaryl (or benzy deriv.) including pyridyl, thienyl, furyl, gps. contg. 2 heteroatoms selected from N, O and S (e.g. pyrazole, imidazol etc.);W = OH, ORa, OCORa, S(O)mRa, S(O)mNRaRb,etc.;W may also be CORa, NRaCORb,etc., if n is other than zero; n = 0-6;R2 = H or (CH2)nL'; L' = M' or W; M' = e.g. (i) phenyl (or benzo deriv.), opt. substd. by 1-3 of 1-3 of OQ, OH, halo, NO2,etc.; R = H or Q; Ra,Rb = H, Q, 2-4C alkenyl, 2-4C alkynyl,etc.; m = 0-2; Q = 1-4C alkyl (or alkylene if appropriate); Q' = 1-6C alkyl (or alkylene if appropriate); provided that R1 and R2 are not both H.
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Inventors:
Bear, Thomas Michael
Sparks, Richard Bruce
Empfield, James Roy
Davenport, Timothy Wayne
McKinney, Jeffrey Alan
Sparks, Richard Bruce
Empfield, James Roy
Davenport, Timothy Wayne
McKinney, Jeffrey Alan
Application Number:
JP51152195A
Publication Date:
May 06, 1997
Filing Date:
October 20, 1994
Export Citation:
Assignee:
Zeneca Limited
International Classes:
A61K31/50; A61K31/5025; A61P3/08; A61P3/10; A61P9/10; A61P25/00; A61P25/08; A61P25/28; A61P43/00; C07D215/56; C07D221/04; C07D471/04; C07D471/14; C07D495/14; C07D221/00; C07D237/00; C07D; (IPC1-7): C07D471/04; C07D495/14; C07D471/14; A61K31/50
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)