Title:
【発明の名称】ホウ化メタロポルフィリン及び治療方法
Document Type and Number:
Japanese Patent JPH09505803
Kind Code:
A
Abstract:
Carborane substituted porphyrin compounds complexed with a metal or transition metal have a variety of therapeutic uses. These compounds have been found, for example, selectively to inhibit viral aspartyl proteases. The transition metal complexes are useful both therapeutically in BNCT (boron neutron capture therapy) as well as for MR contrast enhancement. Particularly preferred compounds in accordance with the invention use the dipotassium salt of 2,4-bis-[ alpha , beta -(1,2-dicarbaclosododecaborane carboxy)ethyl]deuteroporphyrin, which is complexed with a metal or a transition metal. These compounds are well solubilized in water, and are suitable for oral administration.
Inventors:
Carl Stephen Bee
Coomaion Theo
Coomaion Theo
Application Number:
JP51085894A
Publication Date:
June 10, 1997
Filing Date:
September 26, 1994
Export Citation:
Assignee:
The Regents of the University of California
International Classes:
A61K31/40; A61P35/00; C07D487/22; C07F5/05; (IPC1-7): C07D487/22; A61K31/40
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)