Title:
血行性間葉細胞
Document Type and Number:
Japanese Patent JPH09510348
Kind Code:
A
Abstract:
The present invention relates to a population of blood borne mammalian cells that express a unique profile of surface markers that includes certain markers typical of connective tissue fibroblasts, and are referred to herein as "blood-borne mesenchymal cells". In particular, it relates to the isolation, characterization and uses of such blood-borne mesenchymal cells. The cells of the present invention can be distinguished from peripheral blood leukocytes by their distinct size, morphology, cell surface phenotype and biologic activities, and are likewise distinguishable from connective tissue fibroblasts by other surface phenotypic markers. These cells proliferate in culture, and in vivo, as demonstrated in animal models, are capable of migrating into wound sites from the blood. Therefore, such blood-borne mesenchymal cells may have a wide range of applications, including, but not limited to, the promotion of wound healing, tissue remodeling, and for gene therapy.
Inventors:
セラミ アントニー
ブカラ リチャード ジェイ
ブカラ リチャード ジェイ
Application Number:
JP52399595A
Publication Date:
October 21, 1997
Filing Date:
March 16, 1994
Export Citation:
Assignee:
ザ ピコワー インスティテュート フォア メディカル リサーチ
International Classes:
G01N33/53; A61P17/00; C12N5/0775; C12N15/09; G01N33/569; A61K35/12; A61K48/00; (IPC1-7): C12N5/06; A61K35/12; C12N15/09; G01N33/53
Attorney, Agent or Firm:
中村 稔 （外６名）