Title:
遺伝子型改変バクテリオファージによる抗菌治療
Document Type and Number:
Japanese Patent JPH09511397
Kind Code:
A
Abstract:
The present invention is directed to bacteriophage therapy, using methods that enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign objects that would tend to reduce the numbers of bacteriophage and/or the efficiency of those phage at killing the host bacteria in an infection. Disclosed is a method of producing bacteriophage modified for anti-HDS purposes, one method being selection by serial passaging, and the other method being genetic engineering of a bacteriophage, so that the modified bacteriophage will remain active in the body for longer periods of time than the wild-type phage.
Inventors:
アディア，サンカー，エル．
カールトン，リチャード，エム．
メリル，カール，アール．
カールトン，リチャード，エム．
メリル，カール，アール．
Application Number:
JP52582895A
Publication Date:
November 18, 1997
Filing Date:
April 05, 1995
Export Citation:
Assignee:
アメリカ合衆国
エクスポネンシャル バイオセラピーズ，インコーポレイテッド
エクスポネンシャル バイオセラピーズ，インコーポレイテッド
International Classes:
A61K9/12; A61K35/66; A61K35/76; A61P31/04; C07K14/01; C12N15/09; C07K14/08; C07K14/47; C12N7/00; C12N7/08; (IPC1-7): C12N15/09; A61K9/12; A61K35/66; C12N7/00
Attorney, Agent or Firm:
遠山 勉 （外３名）