Title:
自己免疫疾患治療用ペプチド
Document Type and Number:
Japanese Patent JPH09511749
Kind Code:
A
Abstract:
The invention refers to peptides consisting of 7 to 20 amino acid residues with the sequenceA-Leu-B-Ser-C-Thr-Ala-Ala-D,in which B and C are each an amino acid or amino acids and A and D are each monomeric or polymeric organic groups, and especially those, in which B is serine, threonine or leucine and/or in which C is threonine, tryptophane, glutamic acid or serine. The monomeric or polymeric organic groups can independently of each other consist especially of one or several amino acid residues, organic aliphatic groups, especially fatty acids or lipopolysaccharides. The peptides according to the invention are preferentially used for the preparation of a therapeutic composition for the treatment of autoimmune diseases, especially for the treatment of uveitis. In this context the peptides are especially useful for the preparation of a therapeutic composition for the immunization against retinal S-antigen or interphotoreceptor retinol binding protein. Tolerance can be induced orally.
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Inventors:
ヴィルドナー，ゲルヒルト
トゥーラウ，シュテファン
トゥーラウ，シュテファン
Application Number:
JP52735195A
Publication Date:
November 25, 1997
Filing Date:
April 21, 1995
Export Citation:
Assignee:
ヴィルドナー，ゲルヒルト
トゥーラウ，シュテファン
トゥーラウ，シュテファン
International Classes:
A61K38/10; A61K38/17; A61P1/04; A61K38/00; A61P25/00; A61P27/02; A61P37/00; C07K7/08; C07K14/47; C07K14/74; (IPC1-7): A61K38/00; A61K38/00; C07K7/08
Attorney, Agent or Firm:
奥山 尚男 （外３名）