Title:
癌の治療および転移の予防
Document Type and Number:
Japanese Patent JPH09512797
Kind Code:
A
Abstract:
A new method for the treatment of cancer in a human particularly malignant tumors, for example those in a breast or breasts, said method comprising the steps of: (1) directly injecting into the tumour a dosage amount of a pharmaceutical composition comprising an effective amount of an anti-cancer drug and/or drug suitable for use to treat cancer (for example about 1 to about 2 mg Novantrone (Mitoxantrone), other chemotherapeutic agent, NSAIDs) and an effective amount of a form of hyaluronic acid, for example hyaluronic acid and/or pharmaceutically acceptable salts thereof preferably sodium hyaluronate having a molecular weight of less than 750,000 daltons (for example 150,000 - 225,000 daltons) (for example about 10 to about 20 mg sodium hyaluronate) in sterile water; and (2) administering systemically, preferably intravenously, a dosage amount of a pharmaceutical composition comprising: (i) an effective amount of a form of hyaluronic acid (for example hyaluronic acid and/or pharmaceutically acceptable salts thereof, preferably sodium hyaluronate having a molecular weight less than 750,000 daltons (for example 150,000 - 225,000 daltons) for example about 100 - 200 mg or more (because of a lack of toxicity and to reduce the side effects of any medicine (for example NSAID) administered therewith if the amount of the form of hyaluronic acid exceeds about 200 mg/70 kg person); (ii) a drug selected from the group comprising: a) a non-steroidal anti-inflammatory drug (NSAID) for example in an amount of from about 30 mg to about 100 mg (for example 30 to 60 mg of tromethanine salt of ketoralac (sold under the trade mark Toradol) and 50 to 100 mg of diclofenac or diclofenac sodium (for example sold under the trade mark Voltarol), b) an anti-cancer drug, and c) a drug suitable for use to treat cancer and combinations thereof optionally together with (iii) an anti-oxidant for example Vitamin C (in one embodiment 25 gm of Vitamin C).
Inventors:
アスキュライ，サミュエル サイモン
フォーク，ルドルフ エドガー
フォーク，ルドルフ エドガー
Application Number:
JP52856495A
Publication Date:
December 22, 1997
Filing Date:
April 28, 1995
Export Citation:
Assignee:
ハイアル ファーマスティカル コーポレイション
International Classes:
A61K31/728; A61K9/00; A61K31/047; A61K31/19; A61K31/192; A61K31/196; A61K31/375; A61K31/405; A61K31/407; A61K31/44; A61K31/5415; A61K31/715; A61K45/06; A61K47/00; A61K47/36; A61P29/00; A61P35/00; A61P35/04; (IPC1-7): A61K31/725; A61K31/375; A61K45/06
Attorney, Agent or Firm:
飯田 伸行