Title:
【発明の名称】縮合複素環化合物またはその塩、その製造法および用途
Document Type and Number:
Japanese Patent JPH10500402
Kind Code:
A
Abstract:
PCT No. PCT/JP95/00829 Sec. 371 Date Jun. 26, 1995 Sec. 102(e) Date Jun. 26, 1995 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/29900 PCT Pub. Date Nov. 9, 1995Compounds represented by the formula: wherein ring A is benzene; Ar is aromatic group; R1, R2 and R3 each stands for H, acyl, hydrocarbon or heterocyclic, or R2 and R3, taken together, may form non-aromatic cyclic hydrocarbon; X is methylene or carbonyl; +E,uns .........+EE is single bond or double bond; when +E,uns .........+EE is single bond, Y is -NR4- (R4 is H, acyl, hydrocarbon or heterocyclic), when +E,uns .........+EE is double bond, Y is N; n is 1-3, provided that, X is carbonyl and, at the same time, R2 and R3, taken together, form non-aromatic cyclic hydrocarbon, +E,uns .........+EE is double bond or R4 is a heterocyclic or -Z(CH2)m-W (Z is methylene or carbonyl, W is optionally substituted amino, and m denotes 0-5), or salts thereof have an excellent GnRH receptor antagonistic action and/or an action of improving sleep disturbances.
Inventors:
Shigenori Okawa
Nobuhiro Fujii
Koichi Kato
Miyamoto Masaomi
Nobuhiro Fujii
Koichi Kato
Miyamoto Masaomi
Application Number:
JP52811595A
Publication Date:
January 13, 1998
Filing Date:
April 26, 1995
Export Citation:
Assignee:
Takeda GmbH
International Classes:
A61K31/55; A61K31/551; A61P5/00; A61P25/20; A61P35/00; C07D243/10; C07D243/12; C07D243/24; C07D243/38; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D405/12; C07D409/12; C07D417/06; C07D471/04; C07D521/00; (IPC1-7): C07D243/24; A61K31/55; C07D243/10; C07D401/06; C07D401/12; C07D403/06; C07D405/12; C07D409/12; C07D417/06
Attorney, Agent or Firm:
Tadao Asahina (1 person outside)