Title:
【発明の名称】特定のスルファターゼ酵素類および/または硫酸化阻害剤の投与による炎症の治療
Document Type and Number:
Japanese Patent JPH10500939
Kind Code:
A
Abstract:
Compositions are administered to a patient (preferably by injection and locally) to treat a variety of conditions including inflammation associated with trauma and with certain aspects of diseases such as rheumatoid arthritis, psoriasis, insulin-dependent diabetes, cutaneous lymphomas, duodenal ulcer, chronic proctitis, lymphocytic thyroiditis, hemorrhagic shock, reperfusion injury during transplantation and multiple sclerosis. The compositions are pharmaceutically acceptable injectable formulations which include an active component in a pharmaceutically acceptable carrier. The active component is a chlorate or selenate which inhibits the natural biochemical sulfation process and/or a sulfatase enzyme which removes a sulfate from a specific position of a saccharide molecule which makes up a part of a natural ligand for L-selectin. Removal of the sulfate from the ligand hinders the ability of the ligand to bind to its natural receptor (i.e. L-selectin) and thereby hinders a biochemical chain of events which results in inflammation.
More Like This:
| WO/2007/114300 | PRESERVATIVE AGENT |
| JP2006510593 | Monitoring and diagnosis of gastric emptying and gastroparesis |
| WO/2021/030474 | ARTICLES AND METHODS FOR ADMINISTRATION OF THERAPEUTIC AGENTS |
Inventors:
Rosen Steven Dee.
Hemaric Stefan
Imai Yasuyuki
Hemaric Stefan
Imai Yasuyuki
Application Number:
JP52417395A
Publication Date:
January 27, 1998
Filing Date:
March 15, 1995
Export Citation:
Assignee:
The Regents of the University of California
International Classes:
A61K33/04; A61K38/45; A61K38/46; A61P1/00; A61P3/08; C12N9/14; A61P11/00; A61P17/00; A61P29/00; A61P37/00; C07K14/705; C12N9/24; (IPC1-7): A61K38/46; A61K33/04; A61K38/46; C12N9/14; C12N9/24
Attorney, Agent or Firm:
Shoichi Hase (2 outside)