Title:
【発明の名称】PTHまたはPTHrPアンタゴニスト
Document Type and Number:
Japanese Patent JPH10502091
Kind Code:
A
Abstract:
PTH or PTHrP compounds having potent antagonistic activity at the PTH/PTHrP receptor in which at least one of the amino acid residues naturally occurring in positions 2 and 10 is replaced by tryptophane or another amino acid residue bearing an aromatic or heteroaromatic group on its side chain, and optionally at least one of the amino acid residues naturally occurring in positions 3 and 6 is further replaced by tryptophane or another amino acid residue bearing an aromatic or heteroaromatic group on its side chain, having pharmacological activity, e.g. prevention or treatment of conditions which are associated with increased plasma calcium caused by excessive release of PTH or PTHrP.
Inventors:
François, Cardino
Fayen, Jean Honoré Em
Gamze, liner
Gomberto, Frank Otto
Fayen, Jean Honoré Em
Gamze, liner
Gomberto, Frank Otto
Application Number:
JP50548996A
Publication Date:
February 24, 1998
Filing Date:
July 27, 1995
Export Citation:
Assignee:
Sand Limited
International Classes:
A61K8/64; A61K38/26; A61P17/00; A61K8/00; A61P35/00; A61P43/00; A61Q5/00; A61Q7/00; A61Q19/00; C07K14/635; A61K38/00; (IPC1-7): C07K14/635; A61K7/06; A61K7/48; A61K38/26
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)