Title:
【発明の名称】アンチメッセンジャー・オリゴヌクレオチド、およびウロキナーゼ受容体遺伝子発現のアンチメッセンジャー・オリゴヌクレオチド阻害による形質転換されたヒト繊維芽細胞の浸潤性表現型のウロキナーゼ受容体復帰変異
Document Type and Number:
Japanese Patent JPH10502823
Kind Code:
A
Abstract:
PCT No. PCT/EP95/02793 Sec. 371 Date Feb. 27, 1997 Sec. 102(e) Date Feb. 27, 1997 PCT Filed Jul. 17, 1995 PCT Pub. No. WO96/03414 PCT Pub. Date Feb. 8, 1996Antisense oligonucleotides optionally stabilized with phosphorotioate residues or analogues, or modified in the whole sugar-phosphate backbone-complementary to the human urokinase receptor messenger RNA-are able to prevent invasiveness of neoplastic cells by inhibiting the overexpression of the receptor itself, directly responsible of the invasive phenotype. Said oligomers are useful as medicaments for the treatment of primary and secondary neoplasias as well as of other pathologies wherein the urokinase receptor gene overexpression is a pathogenic event.
Inventors:
Capachioli, Sergio
Del rotso, mario
Huvi, Gabriella
Quattrone, Arezsandro
Del rotso, mario
Huvi, Gabriella
Quattrone, Arezsandro
Application Number:
JP50542496A
Publication Date:
March 17, 1998
Filing Date:
July 17, 1995
Export Citation:
Assignee:
Consiglio Natsuionare Dere Richiertier
International Classes:
A61K9/127; A61K31/70; A61K48/00; A61P35/00; C12N15/09; C07H21/00; C07H21/04; C12N15/113; A61K38/00; (IPC1-7): C12N15/09; C07H21/04; A61K48/00; A61K31/70; A61K9/127
Attorney, Agent or Firm:
Heiyoshi Odashima