【発明の名称】灌注用溶液並びに疼痛、炎症及びけいれんの抑制法

Title:

【発明の名称】灌注用溶液並びに疼痛、炎症及びけいれんの抑制法

Document Type and Number:

Japanese Patent JPH10510540

Kind Code:

A

Abstract:

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a mu -opioid agonist.

More Like This:

WO2000027374	THE USE OF EXCITATORY AMINO ACID TRANSPORTER INHIBITORS TO REDUCE CNS WHITE MATTER INJURY
JP2007509716	Polymerizable emulsion for tissue engineering
WO/1997/038682	BIPHENYLAMIDO DERIVATIVES AS MELATONERGIC AGENTS

Inventors:

Demopros, Gregory A.
Pearce, Pamela Ann
Hertz, Jeffrey M.

Application Number:

JP51985396A

Publication Date:

October 13, 1998

Filing Date:

December 12, 1995

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Omeros Medical Systems, Inc.

International Classes:

A61K31/00; A61K31/352; A61K45/00; A61K31/4045; A61K31/4164; A61K31/4168; A61K31/4174; A61K31/439; A61K31/4406; A61K31/4427; A61K31/4439; A61K31/444; A61K31/48; A61K31/498; A61K31/506; A61K31/538; A61K38/04; A61K38/06; A61K38/08; A61K38/12; A61K38/17; A61K38/22; A61K38/57; A61K38/58; A61K45/06; (IPC1-7): A61K45/00

Domestic Patent References:

JPH04364124A	1992-12-16
JPS63115818A	1988-05-20
JPH03504602A	1991-10-09
JPH01135721A	1989-05-29
JPS6259222A	1987-03-14
JPS63500720A	1988-03-17
JPS5872515A	1983-04-30

Foreign References:

WO1994003174A1	1994-02-17
WO1994008602A1	1994-04-28

Attorney, Agent or Firm:

Takehiko Yoshimura

Previous Patent: 酵素インヒビターとしての芳香族ヘテロ環誘導体

Next Patent: 常温真珠光沢化濃縮物