Title:
【発明の名称】因子VIIフラグメント82-128およびその血液凝固不全における使用
Document Type and Number:
Japanese Patent JPH10510804
Kind Code:
A
Abstract:
PCT No. PCT/GB95/02946 Sec. 371 Date Aug. 27, 1997 Sec. 102(e) Date Aug. 27, 1997 PCT Filed Dec. 15, 1995 PCT Pub. No. WO96/18654 PCT Pub. Date Jun. 20, 1996The present invention relates to peptide of the amino acid sequence of formula (I): - 82 85 90 - Glu Thr His Lys Asp Asp Gln Leu Ile - - 95 100 - Cys Val Asn Glu Asn Gly Gly Cys Glu Gln - - 105 110 - Tyr Cys Ser Asp His Thr Gly Thr Lys Arg - - 115 120 - Ser Cys Arg Cys His Glu Gly Tyr Ser Leu - - 125 128 - Leu Ala Asp Gly Val Ser Cys Thr (SEQ ID NO. 1) - and functional equivalents thereof in which amino acids in the above stated sequence are modified or absent and wherein at least one of the cysteine residues may be blocked or replaced and wherein any cysteine residues which remain unblocked or unreplaced may be present in a disulphide bonded state. The invention also includes slats and derivatives of said peptides. The peptides and their salts and derivatives are useful in the treatment of blood clotting disorders.
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Inventors:
Husbin, Met
Peter fischer
Awning, larth
Peter fischer
Awning, larth
Application Number:
JP51848296A
Publication Date:
October 20, 1998
Filing Date:
December 15, 1995
Export Citation:
Assignee:
Nicomed Imaging Ayes
International Classes:
C12N15/09; A61K38/43; A61P7/02; A61P9/08; A61P9/10; C07K14/745; C12N9/64; A61K38/00; (IPC1-7): C07K14/745; A61K38/43; C12N15/09
Attorney, Agent or Firm:
Shunichiro Suzuki