Title:
【発明の名称】進行性グリコシル化最終生成物の生成を阻止し、反転するためのチアゾリウム化合物の使用
Document Type and Number:
Japanese Patent JPH10512864
Kind Code:
A
Abstract:
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.
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Inventors:
Cerami Antony
Ulric Petersea
Wargle Dip Earl
Wang Sang Bao
Versan Sara
Eagan John Jay
Ulric Petersea
Wargle Dip Earl
Wang Sang Bao
Versan Sara
Eagan John Jay
Application Number:
JP52237996A
Publication Date:
December 08, 1998
Filing Date:
January 18, 1996
Export Citation:
Assignee:
Alteon Incorporated
The Picower Institute For Medical Research
The Picower Institute For Medical Research
International Classes:
A61K8/49; A61K31/425; A61K31/426; A61K31/428; A61P3/08; A61P13/02; A61P15/00; G01N33/53; A61P27/02; A61Q11/00; A61Q19/00; C07D277/20; C07D277/22; C07D277/24; C07D277/38; C07D277/40; C07D277/64; G01N33/15; A61Q19/08; (IPC1-7): C07D277/22; A61K31/425; C07D277/24; C07D277/40; C07D277/64; G01N33/15; G01N33/53
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)