Title:
【発明の名称】哺乳類宿主の結合組織を治療するための遺伝子導入
Document Type and Number:
Japanese Patent JPH10513441
Kind Code:
A
Abstract:
The subject invention concerns a method of introducing at least one gene encoding a product into at least one cell of a connective tissue of a mammalian host for use in treating the mammalian host including employing recombinant techniques to produce a DNA vector molecule which contains the gene encoding for the product and infecting the connective cell of the mammalian host using the DNA vector molecule using the gene coding for the product. A method is provided for introducing at least one gene encoding a product into at least one cell of a connective tissue of a mammalian host employing non-viral means. In a specific example, isolated synovial cells were infected with a retrovirus comprising a DNA sequence encoding IRAP and the transfected cells administered to an arthritic joint. A method to produce an animal model for the study of connective tissue pathology is also disclosed. Additionally, this invention provides a method of using in vivo a gene encoding and extracellular interleukin-1 binding domain of an interleukin-1 receptor.
Inventors:
Glorioso, Joseph Sea.
Evans, Christopher H.
Robins, Paul Di.
Evans, Christopher H.
Robins, Paul Di.
Application Number:
JP52308196A
Publication Date:
December 22, 1998
Filing Date:
January 25, 1996
Export Citation:
Assignee:
University of Pittsburgh of the Commonwealth System of Higher Education
International Classes:
A01K67/027; A61K9/127; A61K35/35; A61K35/76; A61K38/00; A61K38/17; A61K47/30; A61K48/00; A61K49/00; A61P29/00; C07K14/54; C07K14/545; C07K14/715; C12N5/077; C12N5/10; C12N15/00; C12N15/09; C12N15/85; C12N15/867; C12R1/92; (IPC1-7): A61K48/00; A01K67/027; A61K9/127; A61K35/76; A61K47/30; C12N5/10; C12N15/09
Attorney, Agent or Firm:
Toshiyuki Maruyama (2 outside)