Title:
【発明の名称】新しいカテプシンならびにその阻害のための方法および組成物
Document Type and Number:
Japanese Patent JPH11506923
Kind Code:
A
Abstract:
Methods for inhibiting the secretion of beta -amyloid peptide ( beta AP) from cells comprise administering to the cells certain compounds which inhibit the activity of an approximately 31 kD protease involved in beta AP secretion. The 31 kD protease has been designated Cathepsin Y. Screening methods for beta AP inhibitors rely on determining the activity of test compounds in the presence of Cathepsin Y and a suitable peptide substrate. This invention is also directed to a nucleic acid sequence that encodes Cathepsin Y and the expression and isolation of Cathepsin Y.
Inventors:
Tan, JS.
Sinha, Skanto
Maccon rogue, lisa
Tatsuno, Gwen
John Anderson
Semco, Christopher M. F.
Chrysler, Susanna
Sinha, Skanto
Maccon rogue, lisa
Tatsuno, Gwen
John Anderson
Semco, Christopher M. F.
Chrysler, Susanna
Application Number:
JP50050797A
Publication Date:
June 22, 1999
Filing Date:
April 26, 1996
Export Citation:
Assignee:
Asena Neurosciences, Inc.
International Classes:
C12N15/09; A61K31/165; A61K31/27; A61K31/403; A61K31/404; A61K31/405; A61K31/47; A61K31/472; A61K38/00; A61P25/28; C07D209/20; C07D217/06; C07K5/06; C07K5/065; C07K5/072; C12N9/64; C12Q1/68; (IPC1-7): C12N15/09; A61K31/165; A61K31/27; A61K31/405; A61K31/47; A61K38/00; C12Q1/68
Attorney, Agent or Firm:
Shusaku Yamamoto