Title:
【発明の名称】ビフェニル誘導体の製造方法
Document Type and Number:
Japanese Patent JPH11507625
Kind Code:
A
Abstract:
This application discloses a process for producing 8-[2'-(2(1)-tert-butyl-2H-tetrazol-5-yl) -biphenyl-4-yl-methyl]-2,4-dimethyl-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one (or such a compound wherein a benzyl or p-methoxybenzyl group is present in place of the tert-butyl group) or a salt thereof, said process characterized in (B) transmetallizing bromo[2-[2-(tert-butyl)-2H-tetrazol-5-yl]phenyl]magnesium Grignard reagent with zinc chloride or bromide; and (C) reacting the transmetallized product with 8-[(4-bromophenyl)-methyl]5,8-dihydro-2,4-dimethyl-pyrido[2,3-d]pyrimidin-7(6H-one in the presence of a palladium catalyst to yield the product; wherein throughout the process a benzyl or p-methoxybenzyl group may be present in place of the tert-butyl group.
Inventors:
Giguere, Pierre
Yera, Silvio
Bernache, Michelle
Barrecca, Giuseppe
Castaldi, Graziano
Cannata, Vincenzo
Yera, Silvio
Bernache, Michelle
Barrecca, Giuseppe
Castaldi, Graziano
Cannata, Vincenzo
Application Number:
JP50151697A
Publication Date:
July 06, 1999
Filing Date:
June 06, 1996
Export Citation:
Assignee:
American Home Products Corporation
International Classes:
B01J31/16; C07B61/00; C07D257/04; C07D471/04; C07F3/02; C07F3/06; C07F7/22; (IPC1-7): C07D471/04; C07D257/04; C07F3/06
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)