Title:
【発明の名称】三環式アミノアルキルカルボキサミド;新規なドーパミンD▲下3▼受容体サブタイプに特異的なリガンド
Document Type and Number:
Japanese Patent JPH11508280
Kind Code:
A
Abstract:
Disclosed are compounds of the formula: ion salts thereof wherein: R1-R4 represent organic or inorganic groups; A represents an alkylene group of 2 to 6 carbon atoms optionally substituted with one or more alkyl groups having from 1 to 4 carbon atoms; Y represents methylene, oxygen, sulfur, or NH; and X is either N, C or CH, which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.
More Like This:
Inventors:
Chain, rhino
Yuan, Jun
Tarkauf, Andrew
Yuan, Jun
Tarkauf, Andrew
Application Number:
JP53826197A
Publication Date:
July 21, 1999
Filing Date:
April 23, 1997
Export Citation:
Assignee:
Neurogen Corporation
International Classes:
A61K31/44; A61K31/4427; A61K31/4433; A61K31/47; A61K31/473; A61K31/495; A61K31/535; A61P25/00; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P43/00; C07D221/10; C07D401/12; C07D409/12; C07D471/04; C07D498/04; (IPC1-7): C07D221/10; A61K31/44; A61K31/47; A61K31/495; A61K31/535; C07D401/12; C07D409/12; C07D471/04; C07D498/04
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)