Title:
【発明の名称】抗原提示細胞上にて抗原密度を増加させる方法
Document Type and Number:
Japanese Patent JPH11511968
Kind Code:
A
Abstract:
Disclosed is a method for presenting an antigen in the form of a peptide on the surface of a cell. The method involves inhibiting the activity of an MHC class I pathway-associated component (e.g., a TAP protein or a proteasome or its components) in a cell and contacting the cell with an antigenic peptide to produce a potent antigen presenting cell. The antigen presenting cells of the invention can be administered to a mammal in a method of treating or preventing cancer or infection with a pathogen (e.g., a bacterium or virus). If desired, the antigen presenting cells can be used to stimulate CTL proliferation in vitro, and the resulting effector cells can subsequently be administered to a mammal in a method of therapy.
Inventors:
Neighbor, Shimita Kay
Gilboa, eri
Gilboa, eri
Application Number:
JP50956097A
Publication Date:
October 19, 1999
Filing Date:
August 20, 1996
Export Citation:
Assignee:
Duke University
International Classes:
C12N15/09; A61K31/70; A61K35/14; A61K39/00; A61K48/00; C07K14/11; C07K14/77; C12N5/071; C12N5/10; C12N9/64; C12N15/113; (IPC1-7): C12N15/09; A61K31/70; A61K35/14; A61K48/00; C12N5/10
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)