Title:
【発明の名称】熱ショックタンパク質-抗原複合体で感作した抗原提示細胞を用いる癌及び感染症の免疫療法
Document Type and Number:
Japanese Patent JPH11512433
Kind Code:
A
Abstract:
The present invention relates to methods and compositions for enhancing immunological responses and for the prevention and treatment of infectious diseases or primary and metastatic neoplastic diseases based on the administration of macrophages and/or other antigen presenting cells (APC) sensitized with heat shock proteins non-covalently bound to peptide complexes and/or antigenic components. APC are incubated in the presence of hsp-peptide complexes and/or antigenic components in vitro. The sensitized cells are reinfused into the patient with or without treatment with cytokines including but not limited to interferon- alpha , interferon- alpha , interleukin-2, interleukin-4, interleukin-6 and tumor neurosis factor.
Inventors:
Srivastava, Pramod, Kay.
Application Number:
JP51206497A
Publication Date:
October 26, 1999
Filing Date:
September 11, 1996
Export Citation:
Assignee:
Fordham University
International Classes:
A61K38/00; A61K31/00; A61K35/12; A61K38/19; A61K39/00; A61P31/00; A61P35/00; A61P35/02; (IPC1-7): A61K31/00; A61K31/00; A61K35/12; A61K38/00
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)